Eric Dane died on February 19, 2026, aged 53, after publicly sharing his ALS diagnosis the previous year. His television work introduced him to audiences through two notably different characters: Mark Sloan in Grey's Anatomy and Cal Jacobs in Euphoria.
As Sloan, Dane became a familiar presence in a long-running network drama. Cal offered a darker role years later. Together, the performances show why his career cannot be reduced to a single nickname or the moment that first made him widely recognizable.
Dane also used his public profile to support ALS awareness and research after announcing his diagnosis. In his recorded conversation for Famous Last Words, he reflected on his work and his love for his daughters. The interview was released after his death, adding his own reflections to the performances through which many viewers first knew him.